Proteomic Modeling for HIV-1 Infected Microglia-Astrocyte Crosstalk
PLoS ONE. 2008 Jun 25;3(6):e2507. Wang T, Gong N, Liu J, Kadiu I, Kraft-Terry SD, Mosley RL, Volsky DJ, Ciborowski P, Gendelman HE.
Researchers from the United States and China studied the effects of astrocytes on HIV-1 infected Microglia. In this study they hypothesized that astrocyte-Microglial cross talk contributes to the control of HIV mediated neuropathogenesis. They used IPA to analyze molecules identified by profiling the microglial proteome and found significant correlations with cellular assembly and organization and cell death networks.
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