MicroRNA expression and identification of putative miRNA targets in ovarian cancer
PLoS ONE. 2008 Jun 18;3(6):e2436. Dahiya N, Sherman-Baust CA, Wang TL, Davidson B, Shih IeM, Zhang Y, Wood W 3rd, Becker KG, Morin PJ.
In order to better define the clinical and biological features of ovarian cancer, researchers from Johns Hopkins Medical Institutions and National Institute of Aging, Baltimore, Maryland, USA, and the Norwegian Radium Hospital, Oslo, Norway identified microRNA expression profiles in human ovarian cancer tissues and cell lines. Using microRNA arrays they identified over 80 differentially expressed miRNAs in ovarian cancer tissues and cell lines including miR_221 (highly up-regulated), miR-21 (down-regulated) and several members of the let-7 family (down-regulated). IPA analysis of the experimentally identified targets of deregulated miRNA identified cancer-relevant pathways and processes commonly targeted by these miRNAs, and also highlighted that the specific molecular pathways targeted by microRNA deregulation are likely tissue and cell-line dependent. Follow up studies elucidating the interactions between these miRNAs, their targets, and the pathways they regulate will serve to identify better markers of ovarian cancer and novel points for therapeutic intervention.
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